Bone Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling of Degenerated Nucleus Pulposus Cells via the miR-101-3p/EIF4G2 Axis

Bone Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling of Degenerated Nucleus Pulposus Cells via the miR-101-3p/EIF4G2 Axis

The etiology of lumbocrural pain is tightly concerned with intervertebral disk degeneration (IDD). Bone mesenchymal stem cell (BMSC)-based therapy bears potentials for IDD treatment. The properties of microRNA (miRNA)-modified BMSCs may be altered. This study investigated the role and mechanism of B...

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Bibliographic Details
Main Authors: Zeng Wang, Xiaolin Ding, Feifei Cao, Xishan Zhang, Jingguo Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
intervertebral disc degeneration
miR-101-3p
EIF4G2
bone mesenchymal stem cells
nucleus pulposus cells
extracellular matrix remodeling
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.642502/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.642502/full

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