Semi-Automated Glycoproteomic Data Analysis of LC-MS Data Using GlycopeptideGraphMS in Process Development of Monoclonal Antibody Biologics

Semi-Automated Glycoproteomic Data Analysis of LC-MS Data Using GlycopeptideGraphMS in Process Development of Monoclonal Antibody Biologics

The glycosylation of antibody-based proteins is vital in translating the right therapeutic outcomes of the patient. Despite this, significant infrastructure is required to analyse biologic glycosylation in various unit operations from biologic development, process development to QA/QC in bio-manufac...

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Bibliographic Details
Main Authors: Kuin Tian Pang, Shi Jie Tay, Corrine Wan, Ian Walsh, Matthew S. F. Choo, Yuan Sheng Yang, Andre Choo, Ying Swan Ho, Terry Nguyen-Khuong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Chemistry
Subjects:
GraphMS
BioAccord
IgG
trastuzumab
adalimumab
glycoproteomic
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.661406/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.661406/full

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