Pediatric Acute Myeloid Leukemia (AML): From Genes to Models Toward Targeted Therapeutic Intervention

Pediatric Acute Myeloid Leukemia (AML): From Genes to Models Toward Targeted Therapeutic Intervention

This review aims to provide an overview of the current knowledge of the genetic lesions driving pediatric acute myeloid leukemia (AML), emerging biological concepts, and strategies for therapeutic intervention. Hereby, we focus on lesions that preferentially or exclusively occur in pediatric patient...

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Bibliographic Details
Main Authors: Thomas Mercher, Juerg Schwaller
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pediatrics
Subjects:
pediatric AML
genomic landscape
mouse models
fusion oncogene
therapeutic targeting
UKBB
Online Access:https://www.frontiersin.org/article/10.3389/fped.2019.00401/full

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https://www.frontiersin.org/article/10.3389/fped.2019.00401/full

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