Pharmacokinetics of Acetaminophen and Metformin Hydrochloride in Rats After Exposure to Simulated High Altitude Hypoxia

Pharmacokinetics of Acetaminophen and Metformin Hydrochloride in Rats After Exposure to Simulated High Altitude Hypoxia

The pharmacokinetic characteristics of drugs were altered under high altitude hypoxia, thereby affecting the absorption, distribution, metabolism, and excretion of drug. However, there are few literatures on the pharmacokinetic changes of antipyretic and pain-relieving drugs and cardiovascular syste...

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Bibliographic Details
Main Authors: Jun-bo Zhu, Jian-xin Yang, Yong-qiong Nian, Gui-qin Liu, Ya-bin Duan, Xue Bai, Qian Wang, Yang Zhou, Xue-jun Wang, Ning Qu, Xiang-yang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
acetaminophen
metformin hydrochloride
high altitude hypoxia
pharmacokinetics
UGT1A1
OCT2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.692349/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.692349/full

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