Subcellular localization of the mouse PRAMEL1 and PRAMEX1 reveals multifaceted roles in the nucleus and cytoplasm of germ cells during spermatogenesis

Subcellular localization of the mouse PRAMEL1 and PRAMEX1 reveals multifaceted roles in the nucleus and cytoplasm of germ cells during spermatogenesis

Abstract Background Preferentially expressed antigen in melanoma (PRAME) is a cancer/testis antigen (CTA) that is predominantly expressed in normal gametogenic tissues and a variety of tumors. Members of the PRAME gene family encode leucine-rich repeat (LRR) proteins that provide a versatile structu...

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Bibliographic Details
Main Authors: Wan-Sheng Liu, Chen Lu, Bhavesh V. Mistry
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Cell & Bioscience
Subjects:
PRAMEL1
PRAMEX1
Cancer-testis antigen
Immunoelectron microscopy
Germ granule
Chromatoid body
Online Access:https://doi.org/10.1186/s13578-021-00612-6

Internet

https://doi.org/10.1186/s13578-021-00612-6

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