Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue

Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue

Perivascular adipose tissue (PVAT) is increasingly being regarded as an important endocrine organ that directly impacts vessel function, structure, and contractility in obesity-associated diseases. We uncover here a role for myeloid G protein-coupled receptor kinase 2 (GRK2) in the modulation of PVA...

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Bibliographic Details
Main Authors: María González-Amor, Rocío Vila-Bedmar, Raquel Rodrigues-Díez, Rosa Moreno-Carriles, Alba C. Arcones, Marta Cruces-Sande, Mercedes Salaices, Federico Mayor, Ana M. Briones, Cristina Murga
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Antioxidants
Subjects:
perivascular adipose tissue (PVAT)
G protein-coupled receptor kinase 2 (GRK2)
tumor necrosis factor-α (TNFα)
NADPH oxidase (Nox)
endothelial dysfunction
Online Access:https://www.mdpi.com/2076-3921/9/10/953

Internet

https://www.mdpi.com/2076-3921/9/10/953

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