The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS).

The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS).

Anthrax lethal toxin (LT) induces vascular insufficiency in experimental animals through unknown mechanisms. In this study, we show that neuronal nitric oxide synthase (nNOS) deficiency in mice causes strikingly increased sensitivity to LT, while deficiencies in the two other NOS enzymes (iNOS and e...

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Bibliographic Details
Main Authors: Mahtab Moayeri, Devorah Crown, David W Dorward, Don Gardner, Jerrold M Ward, Yan Li, Xizhong Cui, Peter Eichacker, Stephen H Leppla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2680977?pdf=render

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