A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds

The present review is a sequel to the previous review on cancer metabolism published in this journal. This review focuses on the selective antiproliferative and cytotoxic effects of mitochondria-targeted therapeutics (MTTs) in cancer cells. Emerging research reveals a key role of mitochondrial respi...

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Bibliographic Details
Main Authors: Balaraman Kalyanaraman, Gang Cheng, Micael Hardy, Olivier Ouari, Marcos Lopez, Joy Joseph, Jacek Zielonka, Michael B. Dwinell
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717306614