Hp-s1 Ganglioside Suppresses Proinflammatory Responses by Inhibiting MyD88-Dependent NF-κB and JNK/p38 MAPK Pathways in Lipopolysaccharide-Stimulated Microglial Cells

Hp-s1 Ganglioside Suppresses Proinflammatory Responses by Inhibiting MyD88-Dependent NF-κB and JNK/p38 MAPK Pathways in Lipopolysaccharide-Stimulated Microglial Cells

Hp-s1 ganglioside is isolated from the sperm of sea urchin (Hemicentrotus pulcherrimus). In addition to neuritogenic activity, the biological function of Hp-s1 in neuroinflammation is unknown. In this study, we investigated the anti-neuroinflammatory effect of Hp-s1 on lipopolysaccharide (LPS)-stimu...

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Bibliographic Details
Main Authors: Jui-Hu Shih, Yow-Fu Tsai, I-Hsun Li, Ming-Hua Chen, Yuahn-Sieh Huang
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Marine Drugs
Subjects:
ganglioside Hp-s1
microglia
lipopolysaccharide
neuroinflammation
Online Access:https://www.mdpi.com/1660-3397/18/10/496

Internet

https://www.mdpi.com/1660-3397/18/10/496

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