Predicting Neuroinflammation in Morphine Tolerance for Tolerance Therapy from Immunostaining Images of Rat Spinal Cord.

Long-term morphine treatment leads to tolerance which attenuates analgesic effect and hampers clinical utilization. Recent studies have sought to reveal the mechanism of opioid receptors and neuroinflammation by observing morphological changes of cells in the rat spinal cord. This work proposes a hi...

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Bibliographic Details
Main Authors: Shinn-Long Lin, Fang-Lin Chang, Shinn-Ying Ho, Phasit Charoenkwan, Kuan-Wei Wang, Hui-Ling Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4593634?pdf=render