A Caspase-Resistant Form of Bcl-XL, but Not Wild Type Bcl-XL, Promotes Clonogenic Survival After Ionizing Radiation

A Caspase-Resistant Form of Bcl-XL, but Not Wild Type Bcl-XL, Promotes Clonogenic Survival After Ionizing Radiation

Bcl-2 and Bcl-XL belong to a family of proteins overexpressed in a variety of human cancers which inhibit apoptosis in response to a number of stimuli including chemotherapeutic agents and ionizing radiation. To better understand the role of these polypeptides in modulating the response of cancer c...

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Bibliographic Details
Main Authors: Alnawaz Rehemtulla, A. Christin Hamilton, Neelam Taneja, Jordan Fridman, Todd S.C. Juan, Jonathan Maybaum, Arul Chinnaiyan
Format: Article
Language:English
Published: Elsevier 1999-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
apoptosis
ionizing radiation
Bcl-X
caspase
survival
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558699800360

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http://www.sciencedirect.com/science/article/pii/S1476558699800360

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