The chaperone domain BRICHOS prevents CNS toxicity of amyloid-β peptide in Drosophila melanogaster

The chaperone domain BRICHOS prevents CNS toxicity of amyloid-β peptide in Drosophila melanogaster

Aggregation of the amyloid-β peptide (Aβ) into toxic oligomers and amyloid fibrils is linked to the development of Alzheimer’s disease (AD). Mutations of the BRICHOS chaperone domain are associated with amyloid disease and recent in vitro data show that BRICHOS efficiently delays Aβ42 oligomerizatio...

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Bibliographic Details
Main Authors: Erik Hermansson, Sebastian Schultz, Damian Crowther, Sara Linse, Bengt Winblad, Gunilla Westermark, Jan Johansson, Jenny Presto
Format: Article
Language:English
Published: The Company of Biologists 2014-06-01
Series:Disease Models & Mechanisms
Subjects:
Amyloid
Alzheimer’s disease
Protein misfolding
Chaperone
Online Access:http://dmm.biologists.org/content/7/6/659

Internet

http://dmm.biologists.org/content/7/6/659

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