Effects of Combinatorial Ubiquitinated Protein-Based Nanovaccine and STING Agonist in Mice With Drug-Resistant and Metastatic Breast Cancer

Effects of Combinatorial Ubiquitinated Protein-Based Nanovaccine and STING Agonist in Mice With Drug-Resistant and Metastatic Breast Cancer

We previously reported that enriched ubiquitinated proteins (UPs) from tumor cells have the potential to be used as immunotherapy vaccine against cancer. Here we enriched UPs from epirubicin (EPB)-induced multi-drug-resistant cancer stem-like breast cancer cell line (4T1/EPB) and tested the efficacy...

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Bibliographic Details
Main Authors: Fang Huang, Ning Pan, Yiting Wei, Jinjin Zhao, Mohanad Aldarouish, Xuru Wang, Xiaotong Sun, Zhifa Wen, Yongqiang Chen, Lixin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
ubiquitinated proteins
breast cancer
cancer vaccines
STING agonist
α-Al2O3 nanoparticles
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.707298/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.707298/full

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