Telomerase Reverse Transcriptase Polymorphism rs2736100: A Balancing Act between Cancer and Non-Cancer Disease, a Meta-Analysis

Telomerase Reverse Transcriptase Polymorphism rs2736100: A Balancing Act between Cancer and Non-Cancer Disease, a Meta-Analysis

The enzyme telomerase reverse transcriptase (TERT) is essential for telomere maintenance. In replicating cells, maintenance of telomere length is important for the preservation of vital genetic information and prevention of genomic instability. A common genetic variant in TERT, rs2736100 C/A, is ass...

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Bibliographic Details
Main Authors: Reinier Snetselaar, Matthijs F. M. van Oosterhout, Jan C. Grutters, Coline H. M. van Moorsel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Medicine
Subjects:
telomerase
telomere
cancer
single nucleotide polymorphism
degenerative disease
Online Access:http://journal.frontiersin.org/article/10.3389/fmed.2018.00041/full

Internet

http://journal.frontiersin.org/article/10.3389/fmed.2018.00041/full

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