Endogenous fluctuations of OCT4 and SOX2 bias pluripotent cell fate decisions

Endogenous fluctuations of OCT4 and SOX2 bias pluripotent cell fate decisions

Abstract SOX2 and OCT4 are pioneer transcription factors playing a key role in embryonic stem (ES) cell self‐renewal and differentiation. How temporal fluctuations in their expression levels bias lineage commitment is unknown. Here, we generated knock‐in reporter fusion ES cell lines allowing to mon...

Full description

Bibliographic Details
Main Authors: Daniel Strebinger, Cédric Deluz, Elias T Friman, Subashika Govindan, Andrea B Alber, David M Suter
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:Molecular Systems Biology
Subjects:
differentiation
embryonic stem cells
endogenous protein fluctuations
OCT4
SOX2
Online Access:https://doi.org/10.15252/msb.20199002

Internet

https://doi.org/10.15252/msb.20199002

Similar Items