Beta-1,3 Oligoglucans Specifically Bind to Immune Receptor CD28 and May Enhance T Cell Activation

Beta-1,3 Oligoglucans Specifically Bind to Immune Receptor CD28 and May Enhance T Cell Activation

Beta glucans are known to have immunomodulatory effects that mediated by a variety of mechanisms. In this article, we describe experiments and simulations suggesting that beta-1,3 glucans may promote activation of T cells by a previously unknown mechanism. First, we find that treatment of a T lympho...

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Bibliographic Details
Main Authors: Jeffrey Comer, Molly Bassette, Riley Burghart, Mayme Loyd, Susumu Ishiguro, Ettayapuram Ramaprasad Azhagiya Singam, Ariela Vergara-Jaque, Ayaka Nakashima, Kengo Suzuki, Brian V. Geisbrecht, Masaaki Tamura
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
beta glucans
oligoglucans
oligomers
CD28
CD3
T cell activation
Online Access:https://www.mdpi.com/1422-0067/22/6/3124

Internet

https://www.mdpi.com/1422-0067/22/6/3124

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