Busulfan systemic exposure and its relationship with efficacy and safety in hematopoietic stem cell transplantation in children: a meta-analysis

Busulfan systemic exposure and its relationship with efficacy and safety in hematopoietic stem cell transplantation in children: a meta-analysis

Abstract Background Busulfan (Bu) is a key component of several conditioning regimens used before hematopoietic stem cell transplantation (HSCT). However, the optimum systemic exposure (expressed as the area under the concentration-time curve [AUC]) of Bu for clinical outcome in children is controve...

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Bibliographic Details
Main Authors: Xinying Feng, Yunjiao Wu, Jingru Zhang, Jiapeng Li, Guanghua Zhu, Duanfang Fan, Changqing Yang, Libo Zhao
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Pediatrics
Subjects:
Busulfan
Area under the concentration-time curve
Efficacy
Veno-occlusive disease
Meta-analysis
Online Access:http://link.springer.com/article/10.1186/s12887-020-02028-6

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http://link.springer.com/article/10.1186/s12887-020-02028-6

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