Determining antibody-binding site of streptococcal pyrogenic exotoxin B to protect mice from group a streptococcus infection.

Determining antibody-binding site of streptococcal pyrogenic exotoxin B to protect mice from group a streptococcus infection.

Streptococcal pyrogenic exotoxin B (SPE B), a cysteine protease, is an important virulence factor in group A streptococcal (GAS) infection. SPE B binds and cleaves antibody isotypes and further impairs the immune system by inhibiting complement activation. In this study, we examined the antibody-bin...

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Bibliographic Details
Main Authors: Nina Tsao, Miao-Hui Cheng, Hsiu-Chen Yang, Yu-Chieh Wang, Yi-Ling Liu, Chih-Feng Kuo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3561455?pdf=render

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http://europepmc.org/articles/PMC3561455?pdf=render

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