An antihypertensive lactoferrin hydrolysate inhibits angiotensin I-converting enzyme, modifies expression of hypertension-related genes and enhances nitric oxide production in cultured human endothelial cells

An antihypertensive lactoferrin hydrolysate inhibits angiotensin I-converting enzyme, modifies expression of hypertension-related genes and enhances nitric oxide production in cultured human endothelial cells

This study was aimed to explore whether an antihypertensive lactoferrin hydrolysate (LFH) can inhibit angiotensin I-converting enzyme (ACE) activity and modify the expression of genes related to hypertension in human umbilical vein endothelial cells (HUVEC). LFH induced significant inhibition of ACE...

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Bibliographic Details
Main Authors: Aurora García-Tejedor, José V. Gimeno-Alcañíz, Sandra Tavárez, Eulalia Alonso, Juan B. Salom, Paloma Manzanares
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Journal of Functional Foods
Subjects:
Lactoferrin hydrolysate
ACE inhibition
Endothelial cells
Transcriptomic analysis
NOSTRIN
Nitric oxide
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464614003417

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http://www.sciencedirect.com/science/article/pii/S1756464614003417

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