The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds in Liquid and Supercritical Fluid Chromatography
Until less than 10 years ago, chiral separations were carried out with columns packed with 5 or 3 μ m fully porous particles (FPPs). Times to resolve enantiomeric mixtures were easily larger than 30 min, or so. Pushed especially by stringent requirements from medicinal and pharmaceutical...
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MDPI AG
2018-10-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/10/2709 |
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doaj-c25b526cadda4c88bf69eccd49b7d15c2020-11-25T00:17:35ZengMDPI AGMolecules1420-30492018-10-012310270910.3390/molecules23102709molecules23102709The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds in Liquid and Supercritical Fluid ChromatographyOmar H. Ismail0Simona Felletti1Chiara De Luca2Luisa Pasti3Nicola Marchetti4Valentina Costa5Francesco Gasparrini6Alberto Cavazzini7Martina Catani8Department of Drug Chemistry and Technology, “Sapienza” University of Rome, P. le Aldo Moro 5, 00185 Rome, ItalyDepartment of Chemistry and Pharmaceutical Sciences, University of Ferrara, via L. Borsari 46, 44121 Ferrara, ItalyDepartment of Chemistry and Pharmaceutical Sciences, University of Ferrara, via L. Borsari 46, 44121 Ferrara, ItalyDepartment of Chemistry and Pharmaceutical Sciences, University of Ferrara, via L. Borsari 46, 44121 Ferrara, ItalyDepartment of Chemistry and Pharmaceutical Sciences, University of Ferrara, via L. Borsari 46, 44121 Ferrara, ItalyDepartment of Chemistry and Pharmaceutical Sciences, University of Ferrara, via L. Borsari 46, 44121 Ferrara, ItalyDepartment of Drug Chemistry and Technology, “Sapienza” University of Rome, P. le Aldo Moro 5, 00185 Rome, ItalyDepartment of Chemistry and Pharmaceutical Sciences, University of Ferrara, via L. Borsari 46, 44121 Ferrara, ItalyDepartment of Chemistry and Pharmaceutical Sciences, University of Ferrara, via L. Borsari 46, 44121 Ferrara, ItalyUntil less than 10 years ago, chiral separations were carried out with columns packed with 5 or 3 μ m fully porous particles (FPPs). Times to resolve enantiomeric mixtures were easily larger than 30 min, or so. Pushed especially by stringent requirements from medicinal and pharmaceutical industries, during the last years the field of chiral separations by liquid chromatography has undergone what can be defined a “true revolution”. With the purpose of developing ever faster and efficient method of separations, indeed, very efficient particle formats, such as superficially porous particles (SPPs) orhttp://www.mdpi.com/1420-3049/23/10/2709ultra-high performance liquid chromatography (UHPLC)supercritical fluid chromatography (SFC)ultrafast enantioseparationsbioactive chiral compounds |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Omar H. Ismail Simona Felletti Chiara De Luca Luisa Pasti Nicola Marchetti Valentina Costa Francesco Gasparrini Alberto Cavazzini Martina Catani |
| spellingShingle |
Omar H. Ismail Simona Felletti Chiara De Luca Luisa Pasti Nicola Marchetti Valentina Costa Francesco Gasparrini Alberto Cavazzini Martina Catani The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds in Liquid and Supercritical Fluid Chromatography Molecules ultra-high performance liquid chromatography (UHPLC) supercritical fluid chromatography (SFC) ultrafast enantioseparations bioactive chiral compounds |
| author_facet |
Omar H. Ismail Simona Felletti Chiara De Luca Luisa Pasti Nicola Marchetti Valentina Costa Francesco Gasparrini Alberto Cavazzini Martina Catani |
| author_sort |
Omar H. Ismail |
| title |
The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds in Liquid and Supercritical Fluid Chromatography |
| title_short |
The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds in Liquid and Supercritical Fluid Chromatography |
| title_full |
The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds in Liquid and Supercritical Fluid Chromatography |
| title_fullStr |
The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds in Liquid and Supercritical Fluid Chromatography |
| title_full_unstemmed |
The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds in Liquid and Supercritical Fluid Chromatography |
| title_sort |
way to ultrafast, high-throughput enantioseparations of bioactive compounds in liquid and supercritical fluid chromatography |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2018-10-01 |
| description |
Until less than 10 years ago, chiral separations were carried out with columns packed with 5 or 3 μ m fully porous particles (FPPs). Times to resolve enantiomeric mixtures were easily larger than 30 min, or so. Pushed especially by stringent requirements from medicinal and pharmaceutical industries, during the last years the field of chiral separations by liquid chromatography has undergone what can be defined a “true revolution”. With the purpose of developing ever faster and efficient method of separations, indeed, very efficient particle formats, such as superficially porous particles (SPPs) or |
| topic |
ultra-high performance liquid chromatography (UHPLC) supercritical fluid chromatography (SFC) ultrafast enantioseparations bioactive chiral compounds |
| url |
http://www.mdpi.com/1420-3049/23/10/2709 |
| work_keys_str_mv |
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