RNA modulators of complex phenotypes in mammalian cells.

RNA-mediated gene silencing, in the form of RNA interference (RNAi) or microRNAs (miRNAs) has provided novel tools for gene discovery and validation in mammalian cells. Here, we report on the construction and application of a random small RNA expression library for use in identifying small interferi...

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Bibliographic Details
Main Authors: Angela Lai, Murray J Cairns, Nham Tran, Hong-Ping Zhang, Lara Cullen, Greg M Arndt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2650256?pdf=render