Pluripotent stem cells secrete Activin A to improve their epiblast competency after injection into recipient embryos

Pluripotent stem cells secrete Activin A to improve their epiblast competency after injection into recipient embryos

Abstract It is not fully clear why there is a higher contribution of pluripotent stem cells (PSCs) to the chimera produced by injection of PSCs into 4-cell or 8-cell stage embryos compared with blastocyst injection. Here, we show that not only embryonic stem cells (ESCs) but also induced pluripotent...

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Bibliographic Details
Main Authors: Jinzhu Xiang, Suying Cao, Liang Zhong, Hanning Wang, Yangli Pei, Qingqing Wei, Bingqiang Wen, Haiyuan Mu, Shaopeng Zhang, Liang Yue, Genhua Yue, Bing Lim, Jianyong Han
Format: Article
Language:English
Published: SpringerOpen 2017-10-01
Series:Protein & Cell
Subjects:
pluripotent stem cells
4-cell embryo injection
secreted proteins
Activin A
chimeric mice
Online Access:http://link.springer.com/article/10.1007/s13238-017-0470-y

Internet

http://link.springer.com/article/10.1007/s13238-017-0470-y

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