Direct mechanical stimulation of tip links in hair cells through DNA tethers

Mechanoelectrical transduction by hair cells commences with hair-bundle deflection, which is postulated to tense filamentous tip links connected to transduction channels. Because direct mechanical stimulation of tip links has not been experimentally possible, this hypothesis has not been tested. We...

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Bibliographic Details
Main Authors: Aakash Basu, Samuel Lagier, Maria Vologodskaia, Brian A Fabella, AJ Hudspeth
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-06-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/16041