A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover
The Parkinson’s disease‐associated LRRK2 protein is a multidomain Roco protein with GTPase activity. Here the authors use a multidisciplinary approach to characterize the GTPase mechanism of a homologous bacterial Roco protein and give mechanistic insights into disease-causing LRRK2 mutations.
Bibliographic Details
Main Authors: |
Egon Deyaert,
Lina Wauters,
Giambattista Guaitoli,
Albert Konijnenberg,
Margaux Leemans,
Susanne Terheyden,
Arsen Petrovic,
Rodrigo Gallardo,
Laura M. Nederveen-Schippers,
Panagiotis S. Athanasopoulos,
Henderikus Pots,
Peter J. M. Van Haastert,
Frank Sobott,
Christian Johannes Gloeckner,
Rouslan Efremov,
Arjan Kortholt,
Wim Versées |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2017-10-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-017-01103-4
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