Nickel ions selectively inhibit lipopolysaccharide-induced interleukin-6 production by decreasing its mRNA stability.

Nickel ions selectively inhibit lipopolysaccharide-induced interleukin-6 production by decreasing its mRNA stability.

Nickel (Ni) ions easily elute from many alloys and elicit inflammation and allergies. Previous studies have shown that infections due to the implantation of medical devices cause inflammation and enhance the elution of Ni ions (Ni²⁺). However, cross-talk between infection- and Ni²⁺-induced signaling...

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Bibliographic Details
Main Authors: Sanki Asakawa, Yu Kishimoto, Takayuki Takano, Kiyuki Okita, Shiho Takakuwa, Taiki Sato, Masahiro Hiratsuka, Osamu Takeuchi, Noriyasu Hirasawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4351189?pdf=render

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http://europepmc.org/articles/PMC4351189?pdf=render

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