Acute D-serine Co-agonism of β-cell NMDA Receptors Potentiates Glucose-Stimulated Insulin Secretion and Excitatory β-cell Membrane Activity

Acute D-serine Co-agonism of β-cell NMDA Receptors Potentiates Glucose-Stimulated Insulin Secretion and Excitatory β-cell Membrane Activity

Insulin-secreting pancreatic β-cells express proteins characteristic of D-serine regulated synapses, but the acute effect of D-serine co-agonism on its presumptive β-cell target, N-methyl D-aspartate receptors (NMDARs), is unclear. We used multiple models to evaluate glucose homeostasis and insulin...

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Bibliographic Details
Main Authors: Amber Lockridge, Eric Gustafson, Alicia Wong, Robert F. Miller, Emilyn U. Alejandro
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
β-cell
D-serine
glucose homeostasis
insulin secretion
mice
Grin1
Online Access:https://www.mdpi.com/2073-4409/10/1/93

Internet

https://www.mdpi.com/2073-4409/10/1/93

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