Inhibition of GSK3β and RIP1K Attenuates Glial Scar Formation Induced by Ischemic Stroke via Reduction of Inflammatory Cytokine Production

Inhibition of GSK3β and RIP1K Attenuates Glial Scar Formation Induced by Ischemic Stroke via Reduction of Inflammatory Cytokine Production

In the chronic phase following ischemic stroke, glial scars can prevent axonal regeneration and the intensification of inflammation. The protective effect of inhibition of glycogen synthase kinase-3β (GSK3β) or receptor-interacting protein 1 kinase (RIP1K) on ischemic stroke has been previously repo...

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Bibliographic Details
Main Authors: Jin Liu, Yong-Ming Zhu, Yi Guo, Liang Lin, Zhan-Xiang Wang, Feng Gu, Xin-Yi Dong, Ming Zhou, Yi-Fan Wang, Hui-Ling Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
ischemic stroke
glial scar
astrocyte
glycogen synthase kinase-3β
receptor-interacting protein 1 kinase
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00812/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00812/full

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