A Novel wx2 Gene of Toxoplasma gondii Inhibits the Parasitic Invasion and Proliferation in vitro and Attenuates Virulence in vivo via Immune Response Modulation

A Novel wx2 Gene of Toxoplasma gondii Inhibits the Parasitic Invasion and Proliferation in vitro and Attenuates Virulence in vivo via Immune Response Modulation

Toxoplasma gondii (T. gondii) is an obligate intracellular apicomplexan protozoan that can parasitize most warm-blooded animals and cause severe diseases in immunocompromised individuals or fetal abnormalities in pregnant woman. The treatment of toxoplamosis has been limited by effective drugs. Our...

Full description

Bibliographic Details
Main Authors: Zhenrong Ma, Kang Yan, Ruolan Jiang, Jie Guan, Linfei Yang, Yehong Huang, Bin Lu, Xuanwu Li, Jie Zhang, Yunfeng Chang, Xiang Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Microbiology
Subjects:
Toxoplasma gondii
CRISPR-Cas9 system
virulence factors
gene knockout
gene functions
wx2 gene
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00399/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00399/full

Similar Items