Characterization of LGR5 expression in poorly differentiated colorectal carcinoma with mismatch repair protein deficiency

Characterization of LGR5 expression in poorly differentiated colorectal carcinoma with mismatch repair protein deficiency

Abstract Background Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a promising intestinal stem cell and carcinoma stem cell marker. We examined the relationship between mismatch repair (MMR) protein deficiency and LGR5 expression in poorly differentiated (PD) colorectal carcin...

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Bibliographic Details
Main Authors: Tomoyuki Nakajima, Takeshi Uehara, Mai Iwaya, Yukihiro Kobayashi, Yasuhiro Maruyama, Hiroyoshi Ota
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Cancer
Subjects:
Leucine-rich repeat-containing G-protein-coupled receptor 5
Mismatch repair
Poorly differentiated colorectal carcinoma
RNA in situ hybridization
Online Access:http://link.springer.com/article/10.1186/s12885-020-06791-8

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http://link.springer.com/article/10.1186/s12885-020-06791-8

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