Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid

Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid

Abstract Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of 6-aminopenicillanic, 7-aminocephalosporanic, and 7-aminodesacetoxycephalosporanic acid with 2,5-dihydroxybenzoic acid derivatives to form new penicillin and cephalosporin structures, respectively. The heteromolecular h...

Full description

Bibliographic Details
Main Authors: Annett Mikolasch, Elke Hammer, Sabine Witt, Ulrike Lindequist
Format: Article
Language:English
Published: SpringerOpen 2020-10-01
Series:AMB Express
Subjects:
Laccase
Biotransformation
ß-lactam antibiotics
Antibacterial activity
Online Access:http://link.springer.com/article/10.1186/s13568-020-01117-0

Internet

http://link.springer.com/article/10.1186/s13568-020-01117-0

Similar Items