Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid
Abstract Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of 6-aminopenicillanic, 7-aminocephalosporanic, and 7-aminodesacetoxycephalosporanic acid with 2,5-dihydroxybenzoic acid derivatives to form new penicillin and cephalosporin structures, respectively. The heteromolecular h...
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| Format: | Article |
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SpringerOpen
2020-10-01
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| Series: | AMB Express |
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| Online Access: | http://link.springer.com/article/10.1186/s13568-020-01117-0 |
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doaj-c27cf96cb5814ed1ba9daab88f4f4e132020-11-25T02:47:53ZengSpringerOpenAMB Express2191-08552020-10-011011710.1186/s13568-020-01117-0Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acidAnnett Mikolasch0Elke Hammer1Sabine Witt2Ulrike Lindequist3Institute of Microbiology, University GreifswaldInterfaculty Institute for Genetics and Functional Genomics, University GreifswaldBiometecInstitute of Pharmacy University GreifswaldAbstract Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of 6-aminopenicillanic, 7-aminocephalosporanic, and 7-aminodesacetoxycephalosporanic acid with 2,5-dihydroxybenzoic acid derivatives to form new penicillin and cephalosporin structures, respectively. The heteromolecular hybrid dimers are formed by nuclear amination of the p-hydroquinones with the primary amines and inhibited in vitro the growth of Staphylococcus species, including some multidrug-resistant strains.http://link.springer.com/article/10.1186/s13568-020-01117-0LaccaseBiotransformationß-lactam antibioticsAntibacterial activity |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Annett Mikolasch Elke Hammer Sabine Witt Ulrike Lindequist |
| spellingShingle |
Annett Mikolasch Elke Hammer Sabine Witt Ulrike Lindequist Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid AMB Express Laccase Biotransformation ß-lactam antibiotics Antibacterial activity |
| author_facet |
Annett Mikolasch Elke Hammer Sabine Witt Ulrike Lindequist |
| author_sort |
Annett Mikolasch |
| title |
Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid |
| title_short |
Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid |
| title_full |
Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid |
| title_fullStr |
Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid |
| title_full_unstemmed |
Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid |
| title_sort |
laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid |
| publisher |
SpringerOpen |
| series |
AMB Express |
| issn |
2191-0855 |
| publishDate |
2020-10-01 |
| description |
Abstract Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of 6-aminopenicillanic, 7-aminocephalosporanic, and 7-aminodesacetoxycephalosporanic acid with 2,5-dihydroxybenzoic acid derivatives to form new penicillin and cephalosporin structures, respectively. The heteromolecular hybrid dimers are formed by nuclear amination of the p-hydroquinones with the primary amines and inhibited in vitro the growth of Staphylococcus species, including some multidrug-resistant strains. |
| topic |
Laccase Biotransformation ß-lactam antibiotics Antibacterial activity |
| url |
http://link.springer.com/article/10.1186/s13568-020-01117-0 |
| work_keys_str_mv |
AT annettmikolasch laccasecatalyzedderivatizationof6aminopenicillanic7aminocephalosporanicand7aminodesacetoxycephalosporanicacid AT elkehammer laccasecatalyzedderivatizationof6aminopenicillanic7aminocephalosporanicand7aminodesacetoxycephalosporanicacid AT sabinewitt laccasecatalyzedderivatizationof6aminopenicillanic7aminocephalosporanicand7aminodesacetoxycephalosporanicacid AT ulrikelindequist laccasecatalyzedderivatizationof6aminopenicillanic7aminocephalosporanicand7aminodesacetoxycephalosporanicacid |
| _version_ |
1724750558323015680 |