The secretome of Pichia pastoris in fed‐batch cultivations is largely independent of the carbon source but changes quantitatively over cultivation time

Summary The quantitative changes of the secretome of recombinant Pichia pastoris (Komagataella phaffii) CBS7435 over the time‐course of methanol‐ or glucose‐limited fed‐batch cultures were investigated by LC‐ESI‐MS/MS to define the carbon source‐specific secretomes under controlled bioreactor condit...

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Bibliographic Details
Main Authors: Jonas Burgard, Clemens Grünwald‐Gruber, Friedrich Altmann, Jürgen Zanghellini, Minoska Valli, Diethard Mattanovich, Brigitte Gasser
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:Microbial Biotechnology
Online Access:https://doi.org/10.1111/1751-7915.13499