Compartmentalized Reconstitution of Post-squalene Pathway for 7-Dehydrocholesterol Overproduction in Saccharomyces cerevisiae

Compartmentalized Reconstitution of Post-squalene Pathway for 7-Dehydrocholesterol Overproduction in Saccharomyces cerevisiae

7-Dehydrocholesterol (7-DHC) is the direct precursor to manufacture vitamin D3. Our previous study has achieved 7-DHC synthesis in Saccharomyces cerevisiae based on the endogenous post-squalene pathway. However, the distribution of post-squalene enzymes between the endoplasmic reticulum (ER) and lip...

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Bibliographic Details
Main Authors: Xiao-Jing Guo, Ming-Dong Yao, Wen-Hai Xiao, Ying Wang, Guang-Rong Zhao, Ying-Jin Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Microbiology
Subjects:
compartmentation
endoplasmic reticulum
lipid bodies
post-squalene pathway
7-dehydrocholesterol
Saccharomyces cerevisiae
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.663973/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2021.663973/full

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