Stereotactically Injected Kv1.2 and CASPR2 Antisera Cause Differential Effects on CA1 Synaptic and Cellular Excitability, but Both Enhance the Vulnerability to Pro-epileptic Conditions

Stereotactically Injected Kv1.2 and CASPR2 Antisera Cause Differential Effects on CA1 Synaptic and Cellular Excitability, but Both Enhance the Vulnerability to Pro-epileptic Conditions

PurposeWe present a case of voltage-gated potassium channel (VGKC) complex antibody-positive limbic encephalitis (LE) harboring autoantibodies against Kv1.2. Since the patient responded well to immunotherapy, the autoantibodies were regarded as pathogenic. We aimed to characterize the pathophysiolog...

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Bibliographic Details
Main Authors: Timo Kirschstein, Erika Sadkiewicz, Gerda Hund-Göschel, Juliane Becker, Xiati Guli, Steffen Müller, Marco Rohde, Dora-Charlotte Hübner, Hannes Brehme, Stephan Kolbaske, Katrin Porath, Tina Sellmann, Annette Großmann, Matthias Wittstock, Steffen Syrbe, Alexander Storch, Rüdiger Köhling
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
limbic encephalitis
voltage-gated potassium channel
synaptic transmission
long-term potentiation
spike frequency adaptation
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2020.00013/full

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https://www.frontiersin.org/article/10.3389/fnsyn.2020.00013/full

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