ONX 0914 Lacks Selectivity for the Cardiac Immunoproteasome in CoxsackievirusB3 Myocarditis of NMRI Mice and Promotes Virus-Mediated Tissue Damage

ONX 0914 Lacks Selectivity for the Cardiac Immunoproteasome in CoxsackievirusB3 Myocarditis of NMRI Mice and Promotes Virus-Mediated Tissue Damage

<b>:</b> Inhibition of proteasome function by small molecules<b> </b>is highly efficacious in cancer treatment. Other than non-selective proteasome inhibitors, immunoproteasome-specific inhibitors allow for specific targeting of the proteasome in immune cells and the profound...

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Bibliographic Details
Main Authors: Hannah Louise Neumaier, Shelly Harel, Karin Klingel, Ziya Kaya, Arnd Heuser, Meike Kespohl, Antje Beling
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
myocarditis
proteasome
immunoproteasome inhibitor
inflammation
proteostasis
Online Access:https://www.mdpi.com/2073-4409/9/5/1093

Internet

https://www.mdpi.com/2073-4409/9/5/1093

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