Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet.

Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet.

BACKGROUND/AIMS: The senescence marker protein-30 (SMP30) is a 34 kDa protein originally identified in rat liver that shows decreased levels with age. Several functional studies using SMP30 knockout (Smp30(Y/-) ) mice established that SMP30 functions as an antioxidant and protects against apoptosis....

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Bibliographic Details
Main Authors: Yoshitaka Kondo, Goji Hasegawa, Hiroshi Okada, Takafumi Senmaru, Michiaki Fukui, Naoto Nakamura, Morio Sawada, Jo Kitawaki, Takeshi Okanoue, Yuki Kishimoto, Akiko Amano, Naoki Maruyama, Hiroshi Obayashi, Akihito Ishigami
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3670834?pdf=render

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http://europepmc.org/articles/PMC3670834?pdf=render

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