French lyophilized plasma versus normal saline for post-traumatic coagulopathy prevention and correction: PREHO-PLYO protocol for a multicenter randomized controlled clinical trial

French lyophilized plasma versus normal saline for post-traumatic coagulopathy prevention and correction: PREHO-PLYO protocol for a multicenter randomized controlled clinical trial

Abstract Background Post-trauma bleeding induces an acute deficiency in clotting factors, which promotes bleeding and hemorrhagic shock. However, early plasma administration may reduce the severity of trauma-induced coagulopathy (TIC). Unlike fresh frozen plasma, which requires specific hospital log...

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Main Authors: Daniel Jost, Sabine Lemoine, Frederic Lemoine, Vincent Lanoe, Olga Maurin, Clément Derkenne, Marilyn Franchin Frattini, Maëlle Delacote, Edouard Seguineau, Anne Godefroy, Nicolas Hervault, Ludovic Delhaye, Nicolas Pouliquen, Emilie Louis-Delauriere, Julie Trichereau, Florian Roquet, Marina Salomé, Catherine Verret, René Bihannic, Romain Jouffroy, Benoit Frattini, Vivien Hong Tuan Ha, Pascal Dang-Minh, Stéphane Travers, Michel Bignand, Christophe Martinaud, Eliane Garrabe, Sylvain Ausset, Bertrand Prunet, Anne Sailliol, Jean Pierre Tourtier, for the PREHO-PLYO Study Group
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Trials
Subjects:
Post-trauma coagulopathy
Lyophilized plasma transfusion
Hemorrhagic shock
Shock index
Prehospital emergency care
Advanced trauma life support
Online Access:https://doi.org/10.1186/s13063-020-4049-1

Internet

https://doi.org/10.1186/s13063-020-4049-1

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