MAP3K4 Controls the Chromatin Modifier HDAC6 during Trophoblast Stem Cell Epithelial-to-Mesenchymal Transition

MAP3K4 Controls the Chromatin Modifier HDAC6 during Trophoblast Stem Cell Epithelial-to-Mesenchymal Transition

The first epithelial-to-mesenchymal transition (EMT) occurs in trophoblast stem (TS) cells during implantation. Inactivation of the serine/threonine kinase MAP3K4 in TS cells (TSKI4 cells) induces an intermediate state of EMT, where cells retain stemness, lose epithelial markers, and gain mesenchyma...

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Bibliographic Details
Main Authors: Robert J. Mobley, Deepthi Raghu, Lauren D. Duke, Kayley Abell-Hart, Jon S. Zawistowski, Kyla Lutz, Shawn M. Gomez, Sujoy Roy, Ramin Homayouni, Gary L. Johnson, Amy N. Abell
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
epithelial to mesenchymal transition
epigenetics
chromatin remodelers
MAP3K4
trophoblast stem cells
histone deacetylase
HDAC6
tight junctions
histone acetylation
development
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302115

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http://www.sciencedirect.com/science/article/pii/S2211124717302115

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