3,3′,5-Triiodothyroacetic acid (TRIAC) induces embryonic ζ-globin expression via thyroid hormone receptor α

3,3′,5-Triiodothyroacetic acid (TRIAC) induces embryonic ζ-globin expression via thyroid hormone receptor α

Abstract The human ζ-globin gene (HBZ) is transcribed in primitive erythroid cells only during the embryonic stages of development. Reactivation of this embryonic globin synthesis would likely alleviate symptoms both in α-thalassemia and sickle-cell disease. However, the molecular mechanisms control...

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Bibliographic Details
Main Authors: Huiqiao Chen, Zixuan Wang, Shanhe Yu, Xiao Han, Yun Deng, Fuhui Wang, Yi Chen, Xiaohui Liu, Jun Zhou, Jun Zhu, Hao Yuan
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Hematology & Oncology
Subjects:
ζ-Globin
Thyroid hormone
Thalassemia
Sickle-cell disease
Online Access:https://doi.org/10.1186/s13045-021-01108-z

Internet

https://doi.org/10.1186/s13045-021-01108-z

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