Intravenous Delivery of <em>piggy</em>Bac Transposons as a Useful Tool for Liver-Specific Gene-Switching

Intravenous Delivery of <em>piggy</em>Bac Transposons as a Useful Tool for Liver-Specific Gene-Switching

Hydrodynamics-based gene delivery (HGD) is an efficient method for transfecting plasmid DNA into hepatocytes in vivo. However, the resulting gene expression is transient, and occurs in a non-tissue specific manner. The <i>piggy</i>Bac (PB) transposon system allows chromosomal integration...

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Bibliographic Details
Main Authors: Shingo Nakamura, Masayuki Ishihara, Satoshi Watanabe, Naoko Ando, Masato Ohtsuka, Masahiro Sato
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
Cre/<i>loxP</i>
diphtheria toxin-A chain
EGFP
hepatic disorder
hydrodynamics-based gene delivery
in vivo gene delivery
liver
<i>piggy</i>Bac transposon
Online Access:https://www.mdpi.com/1422-0067/19/11/3452

Internet

https://www.mdpi.com/1422-0067/19/11/3452

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