An evolutionary driver of interspersed segmental duplications in primates

An evolutionary driver of interspersed segmental duplications in primates

Abstract Background The complex interspersed pattern of segmental duplications in humans is responsible for rearrangements associated with neurodevelopmental disease, including the emergence of novel genes important in human brain evolution. We investigate the evolution of LCR16a, a putative driver...

Full description

Bibliographic Details
Main Authors: Stuart Cantsilieris, Susan M. Sunkin, Matthew E. Johnson, Fabio Anaclerio, John Huddleston, Carl Baker, Max L. Dougherty, Jason G. Underwood, Arvis Sulovari, PingHsun Hsieh, Yafei Mao, Claudia Rita Catacchio, Maika Malig, AnneMarie E. Welch, Melanie Sorensen, Katherine M. Munson, Weihong Jiang, Santhosh Girirajan, Mario Ventura, Bruce T. Lamb, Ronald A. Conlon, Evan E. Eichler
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Genome Biology
Subjects:
Segmental duplication
Nuclear pore interacting protein
LCR16a
Gene fusion
Genomic instability
Online Access:http://link.springer.com/article/10.1186/s13059-020-02074-4

Internet

http://link.springer.com/article/10.1186/s13059-020-02074-4

Similar Items