A computational model for investigating the evolution of colonic crypts during Lynch syndrome carcinogenesis

A computational model for investigating the evolution of colonic crypts during Lynch syndrome carcinogenesis

Abstract Lynch syndrome (LS), the most common inherited colorectal cancer (CRC) syndrome, increases the cancer risk in affected individuals. LS is caused by pathogenic germline variants in one of the DNA mismatch repair (MMR) genes, complete inactivation of which causes numerous mutations in affecte...

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Bibliographic Details
Main Authors: Saskia Haupt, Nils Gleim, Aysel Ahadova, Hendrik Bläker, Magnus vonKnebel Doeberitz, Matthias Kloor, Vincent Heuveline
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Computational and Systems Oncology
Subjects:
Colonic Crypts
Colorectal Cancer
Carcinogenesis
Lynch Syndrome
Computational Modeling
Voronoi Tessellation Model
Online Access:https://doi.org/10.1002/cso2.1020

Internet

https://doi.org/10.1002/cso2.1020

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