The effects of the DNA Demethylating reagent, 5-azacytidine on SMCHD1 genomic localization

Abstract Background DNA methylation is an epigenetic modification that mainly repress expression of genes essential during embryogenesis and development. There are key ATPase-dependent enzymes that read or write DNA methylation to remodel chromatin and regulate gene expression. Structural maintenanc...

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Bibliographic Details
Main Authors: S. Massah, J. Jubene, F. J. S. Lee, T. V. Beischlag, G. G. Prefontaine
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Genetics
Subjects:
Online Access:https://doi.org/10.1186/s12863-020-0809-x