Clomiphene and Its Isomers Block Ebola Virus Particle Entry and Infection with Similar Potency: Potential Therapeutic Implications

Clomiphene and Its Isomers Block Ebola Virus Particle Entry and Infection with Similar Potency: Potential Therapeutic Implications

The 2014 outbreak of Ebola virus (EBOV) in Western Africa highlighted the need for anti-EBOV therapeutics. Clomiphene is a U.S. Food and Drug Administration (FDA)-approved drug that blocks EBOV entry and infection in cells and significantly protects EBOV-challenged mice. As provided, clomiphene is,...

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Bibliographic Details
Main Authors: Elizabeth A. Nelson, Alyson B. Barnes, Ronald D. Wiehle, Gregory K. Fontenot, Thomas Hoenen, Judith M. White
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Viruses
Subjects:
Ebola
filovirus
enclomiphene
zuclomiphene
anti-viral
Ebola Virus disease
Ebola virus survivors
Online Access:http://www.mdpi.com/1999-4915/8/8/206

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http://www.mdpi.com/1999-4915/8/8/206

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