A critical reappraisal of neutrophil extracellular traps (NETs) and NETosis mimics based on differential requirements for protein citrullination

NETosis, an antimicrobial form of neutrophil cell death, is considered a primary source of citrullinated autoantigens in rheumatoid arthritis (RA) and immunogenic DNA in systemic lupus erythematosus (SLE). Activation of the citrullinating enzyme peptidylarginine deiminase type 4 (PAD4) is believed t...

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Bibliographic Details
Main Authors: Maximilian Ferdinand Konig, Felipe Andrade
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
Subjects:
ROS
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00461/full