Bupivacaine inhibits a small conductance calcium‐activated potassium type 2 channel in human embryonic kidney 293 cells

Bupivacaine inhibits a small conductance calcium‐activated potassium type 2 channel in human embryonic kidney 293 cells

Abstract Background Bupivacaine blocks many ion channels in the heart muscle, causing severe cardiotoxicity. Small-conductance calcium-activated potassium type 2 channels (SK2 channels) are widely distributed in the heart cells and are involved in relevant physiological functions. However, whether b...

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Bibliographic Details
Main Authors: Hongfei Chen, Zhousheng Jin, Fangfang Xia, Zhijian Fu
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Pharmacology and Toxicology
Subjects:
Bupivacaine
Cardiotoxicity
HEK293 cells
Inhibition
SK2 channel
Online Access:https://doi.org/10.1186/s40360-021-00481-2

Internet

https://doi.org/10.1186/s40360-021-00481-2

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