Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance.

Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance.

Variation of the gene coding for D2 receptors (DRD2) has been associated with risk for schizophrenia and with working memory deficits. A functional intronic SNP (rs1076560) predicts relative expression of the two D2 receptors isoforms, D2S (mainly pre-synaptic) and D2L (mainly post-synaptic). Howeve...

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Bibliographic Details
Main Authors: Alessandro Bertolino, Paolo Taurisano, Nicola Marco Pisciotta, Giuseppe Blasi, Leonardo Fazio, Raffaella Romano, Barbara Gelao, Luciana Lo Bianco, Madia Lozupone, Annabella Di Giorgio, Grazia Caforio, Fabio Sambataro, Artor Niccoli-Asabella, Audrey Papp, Gianluca Ursini, Lorenzo Sinibaldi, Teresa Popolizio, Wolfgang Sadee, Giuseppe Rubini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2825256?pdf=render

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http://europepmc.org/articles/PMC2825256?pdf=render

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