Integration of multiscale dendritic spine structure and function data into systems biology models

Integration of multiscale dendritic spine structure and function data into systems biology models

Comprising 1011 neurons with 1014 synaptic connections the human brain is the ultimate systems biology puzzle. An increasing body of evidence highlights the observation that changes in brain function, both normal and pathological, consistently correlate with dynamic changes in neuronal anatomy. An...

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Bibliographic Details
Main Authors: James J Mancuso, Jie eCheng, Zheng eYin, Jared C. Gilliam, Xiaofeng eXia, Xuping eLi, Stephen T.C. Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Neuroanatomy
Subjects:
Dendritic Spines
Microscopy
Systems Biology
big data
image analysis
Modeling and simulations
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnana.2014.00130/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnana.2014.00130/full

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