HIV-1-Specific CAR-T Cells With Cell-Intrinsic PD-1 Checkpoint Blockade Enhance Anti-HIV Efficacy in vivo

HIV-1-Specific CAR-T Cells With Cell-Intrinsic PD-1 Checkpoint Blockade Enhance Anti-HIV Efficacy in vivo

Adoptive cellular immunotherapy therapy using broadly neutralizing antibody-based chimeric antigen receptor-T cells (bNAb-based CAR-T) has shown great potency and safety for the functional cure of HIV. The efficacy of bNAb-based CAR-T cells could be compromised by adaptive resistance during HIV chro...

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Bibliographic Details
Main Authors: Zhengtao Jiang, Huitong Liang, Hanyu Pan, Yue Liang, Hua Wang, Xinyi Yang, Panpan Lu, Xiao Zhang, Jinlong Yang, Dengji Zhang, Xiaoting Shen, Jing Wang, Zhiming Liang, Qinru Lin, Yanan Wang, Lin Zhao, Yangcheng Zhong, Hongzhou Lu, Huanzhang Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Microbiology
Subjects:
HIV-1 functional cure
cellular immunotherapy
CAR-T
PD-1/PD-L1
immune checkpoint
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.684016/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2021.684016/full

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