The Course of AαVal541 as a Proteinase 3 Specific Neo-Epitope after Alpha-1-Antitrypsin Augmentation in Severe Deficient Patients

The Course of AαVal541 as a Proteinase 3 Specific Neo-Epitope after Alpha-1-Antitrypsin Augmentation in Severe Deficient Patients

In alpha-1-antitrypsin deficiency (AATD), neutrophil serine proteases such as elastase and proteinase 3 (PR3) are insufficiently inhibited. A previous study in AATD patients showed a higher plasma level of the specific PR3-generated fibrinogen-derived peptide AαVal541, compared with healthy controls...

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Bibliographic Details
Main Authors: Iris G. M. Schouten, Richard A. Mumford, Dirk Jan A. R. Moes, Pieter S. Hiemstra, Jan Stolk
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
alpha-1-antitrypsin deficiency
proteinase 3
alpha-1-antitrypsin augmentation therapy
biomarker
Online Access:https://www.mdpi.com/1422-0067/22/15/8031

Internet

https://www.mdpi.com/1422-0067/22/15/8031

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